Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia: Is there an Immune Mediated Etiopathologic Relationship with Neural Crest Cell Derivatives and Ciliary Body Stem Cells?
نویسنده
چکیده
Vogt Koyanagi Harada disease (VKH) is a multisystem disorder of an unknown, possibly immune etiology. Sympathetic ophthalmia is also a bilateral panuveitis of presumed immune origin where the inciting stimulus is an injury to the eyeball. The etiopathogenesis of these two diseases which manifest as panuveitis remains poorly understood. In this review, an effort is made to draw a possible etiological association between ciliary body stem/ progenitor cells and sympathetic ophthalmia and one between Vogt-Koyanagi-Harada disease and neural derived crest cells.
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Reversible alopecia in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia
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Vogt-Koyanagi-Harada disease (VKH) and sympathetic ophthalmia (SO) are types of T-cell mediated autoimmune granulomatous uveitis. Although the two diseases share common clinical features, they have certain differences in gender predilections. VKH classically has been reported as more prevalent in females than males, yet some studies in Japan and China have not found differences in gender preval...
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Aims: To investigate the usefulness of ultrasound biomicroscopy for evaluating changes in the ciliary body in patients with Vogt-Koyanagi-Harada disease. Methods: Ultrasound biomicroscopy was used to evaluate 14 eyes of seven patients diagnosed with Vogt-Koyanagi-Harada disease. Cross sectional images of the ciliary body and thickness of the pars plana 3.0 mm posterior to the scleral spur were ...
متن کاملVogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes
Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair. This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral trigger in the presence of HLA-DRB1*0405 allele. The absence of ocular trauma or previous intraocular surgery sets VKHD appart from sympathetic...
متن کاملUltrasound biomicroscopic study of ciliary body changes in the post-treatment phase of Vogt-Koyanagi-Harada disease.
AIMS To investigate the usefulness of ultrasound biomicroscopy for evaluating changes in the ciliary body in patients with Vogt-Koyanagi-Harada disease. METHODS Ultrasound biomicroscopy was used to evaluate 14 eyes of seven patients diagnosed with Vogt-Koyanagi-Harada disease. Cross sectional images of the ciliary body and thickness of the pars plana 3.0 mm posterior to the scleral spur were ...
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تاریخ انتشار 2016